叶酸缺乏和宫发育不良
C E Butterworth1, K D Hatch, M Macaluso
1Department of Nutrition Sciences, School of Medicine, University of Alabama, Birmingham 35294-3360.
JAMA
|February 1, 1992
概括
营养缺乏,特别是红细胞叶酸的低水平,显著增加了年轻妇女的宫发育不良的风险,特别是当结合人类乳头瘤病毒 (HPV) 感染.
科学领域:
- 妇科 妇科 妇科 妇科
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 宫发育不良是一种影响年轻女性的癌前疾病.
- 了解风险因素,包括营养状况,对于预防至关重要.
研究的目的:
- 调查营养缺乏症与年轻女性宫发育不良的发生率之间的联系.
- 为了确定特定的营养水平是否会影响发展宫发育不良的风险.
主要方法:
- 一项涉及726名妇女的病例控制研究,这些妇女从计划生育诊所和结肠镜转诊接受了查.
- 使用后勤回归模型来评估宫发育不良和各种因素之间的关联,包括从血液样本中获得的12个营养指数.
- 分析了人类乳头瘤病毒 (HPV) 感染和营养水平.
主要成果:
- 在宫发育不良症和性伴侣数量,平价,口服避孕药的使用和HPV-16感染之间发现了显著的关联.
- 血营养水平一般没有与风险相关.
- 低红细胞叶酸水平 (<660nmol/L) 与HPV-16感染有显著的相互作用,使HPV-16的调整几率比率增加到5.1.
结论:
- 低红细胞叶酸水平可能会增加宫发育不良的风险.
- 叶酸缺乏特别增强了HPV-16感染对宫发育不良的作用.
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