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Updated: May 11, 2026

Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions
Published on: October 21, 2016
结构生物学:分析蛋白质折叠合作性的分析
1Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, NCI, NIH, Building 37, Room 6114E, Bethesda, Maryland 20892, USA. yawen@helix.nih.gov
小蛋白折叠通常是合作的. 然而,新的分析表明,重新设计的Naf-BBL蛋白通过两种状态的过程展开,符合全或无折叠原则.
科学领域:
- 蛋白质折叠的动态 蛋白质折叠的动态
- 生物物理化学 生物物理化学
- 结构生物学是结构生物学.
背景情况:
- 小蛋白质的折叠通常被认为是一个全或零的过程,具有高度的合作性和显著的动力障碍.
- 最近的研究表明,重新设计的Naf-BBL蛋白在没有实质性的合作或动力障碍的情况下展开.
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