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The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
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相关实验视频

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A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
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在长期戒酒的酒者中降低死亡风险.

K D Bullock1, R J Reed, I Grant

  • 1Psychiatry Service, Veterans Affairs Medical Center, San Diego, CA 92161.

JAMA
|February 5, 1992
PubMed
概括

在男性酒鬼中,稳定的戒酒显著降低了与复发相比的死亡风险. 复发性酒者面临的早逝率几乎增加了五倍,这凸显了持续康复的重要性.

科学领域:

  • 成 药物 药物 药物 药物
  • 公共卫生 公共卫生
  • 流行病学 流行病学

背景情况:

  • 酒精依赖是一种慢性复发性疾病,具有重大死亡影响.
  • 了解酒精依赖的长期健康后果,特别是与复发和戒断有关的结果,对于公共卫生至关重要.
  • 以前的研究表明,饮酒障碍患者的死亡率较高,但持续戒酒与复发的具体影响需要进一步阐明.

研究的目的:

  • 为了调查是否实现稳定戒酒的男性酒者死亡率低于复发者.
  • 在一组男性酒鬼中确定过早死亡的预测因素.
  • 开发一个预测模型,以提前死亡的个人与酒精依赖.

主要方法:

  • 一项前性队列研究追踪了199名酒精男性 (通过DSM-III标准诊断) 和98名非酒精对照者,持续了1-11年.
  • 酒精参与者被分为稳定戒酒者或复发者.
  • 使用多个官方记录和个人联系来确定死亡率数据,并计算标准化死亡率 (SMR).

主要成果:

  • 复发性酒者有19例死亡,明显超过预期的数量 (SMR = 4.96,P < .001).
  • 戒酒者有四例死亡,SMR (1.25) 与预期率没有显著差异.
  • 考克斯的比例危险分析显示,复发是增加酒精使用者死亡率的唯一显著预测因素.

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结论:

  • 实现稳定的酒精戒断与与一般人口相比的死亡率有关.
  • 复发的男性酒者表现出明显增加的过早死亡风险,大约是普通人口的4.96倍.
  • 持续的戒酒是缓解与酒精依赖相关的死亡风险的关键因素.