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相关概念视频

The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:16

The DNA Helix

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...

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Efficient assignment and NMR analysis of an intact virus using sequential side-chain correlations and DNP sensitization.

Proceedings of the National Academy of Sciences of the United States of America·2017
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Pf1 bacteriophage hydration by magic angle spinning solid-state NMR.

The Journal of chemical physics·2014
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Helix control in polymers: case of peptide nucleic acids (PNAs).

Artificial DNA, PNA & XNA·2012
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Consequences of cooperativity in racemizing supramolecular systems.

Angewandte Chemie (International ed. in English)·2012
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Methods in molecular biology (Clifton, N.J.)·2011

相关实验视频

Updated: Jul 16, 2026

Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking
16:21

Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking

Published on: March 10, 2014

作为大尺度长度奇拉性源的DNA-蛋白相互作用,这在线状细菌菌体的液晶行为中很明显.

Sonit Tomar1, Mark M Green, Loren A Day

  • 1Department of Chemical and Biological Sciences, Polytechnic University, Brooklyn, New York 11201, USA.

Journal of the American Chemical Society
|February 24, 2007
PubMed
概括

线状菌体形成液晶,其中一些由于结构性状性而表现出阴性相,而另一些则表现出胆固醇相. 这项研究揭示了DNA囊相互作用如何影响这些液晶特性和菌体结构.

科学领域:

  • 生物物理学的生物物理.
  • 材料科学 材料科学 材料科学
  • 结构生物学 结构生物学

背景情况:

  • 丝状菌体是螺旋状病毒,具有性蛋白质子单元.
  • 它们的自我组装成有序的结构可以导致液晶相.
  • 了解这些结构是病毒组装和功能的关键.

研究的目的:

  • 为了研究八种不同的线状菌体的液晶性质.
  • 探索菌体结构,性和液晶相形成之间的关系.
  • 确定与DNA和蛋白质成分的相互作用如何影响这些特性.

主要方法:

  • 研究了八种线状菌体 (fd,IKe,I(2)2,X-2,Pf1,Pf3,tf-1和X).
  • 观察到由这些菌体形成的液晶相 (内马特和胆固醇).
  • 引入的剂与DNA或蛋白质成分相互作用,改变菌体的特性.
  • 分析了DNA-囊体对称性和子单元等价性.

主要成果:

  • 一些菌体形成了阴性液晶,对成分性不敏感.
  • 其他人形成了胆固醇液晶,显示出不寻常的结构性.
  • 补充剂的添加改变了八种菌体中的七种菌体的液晶特性.

更多相关视频

Visualization of DNA Compaction in Cyanobacteria by High-voltage Cryo-electron Tomography
09:47

Visualization of DNA Compaction in Cyanobacteria by High-voltage Cryo-electron Tomography

Published on: July 17, 2018

Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified λ DNA at the Single Molecule Level
08:56

Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified λ DNA at the Single Molecule Level

Published on: July 17, 2018

相关实验视频

Last Updated: Jul 16, 2026

Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking
16:21

Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking

Published on: March 10, 2014

Visualization of DNA Compaction in Cyanobacteria by High-voltage Cryo-electron Tomography
09:47

Visualization of DNA Compaction in Cyanobacteria by High-voltage Cryo-electron Tomography

Published on: July 17, 2018

Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified λ DNA at the Single Molecule Level
08:56

Visualizing the Interaction Between the Qdot-labeled Protein and Site-specifically Modified λ DNA at the Single Molecule Level

Published on: July 17, 2018

  • 在DNA-囊体对称性的差异导致多态和丝线圈,导致胆固醇阶段.

    • 结论:

    • 线状菌体结构和DNA-囊体相互作用决定了液晶阶段的形成.
    • 菌体组件中的性可以导致不同的液晶行为 (阴性与胆固醇).
    • 液晶形成是研究菌体多态和结构的工具.