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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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相关实验视频

Updated: May 8, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

表观遗传学:一个景观正在成形.

Aaron D Goldberg1, C David Allis, Emily Bernstein

  • 1Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA.

Cell
|February 27, 2007
PubMed
概括
此摘要是机器生成的。

表观遗传学是一个快速发展的领域. 这篇文章探讨了它的哲学基础,分子机制,以及在表观遗传学研究中的未来研究方向.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

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相关实验视频

Last Updated: May 8, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 发育生物学 发展生物学

背景情况:

  • 表观遗传学已经从不同的观察转变为一个凝聚在一起的科学学科.
  • 了解超越DNA序列的基因调节至关重要.

研究的目的:

  • 检查表观遗传学的认识论.
  • 提供表观遗传分子机制的概述.
  • 在表观遗传学研究中确定未来的挑战和机会.

主要方法:

  • 文献综述和综合 文献综述和综合
  • 对表观遗传原理的概念分析.
  • 讨论当前的研究趋势.

主要成果:

  • 表观遗传学为理解基因表达的遗传性变化提供了一个框架.
  • 关键的分子机制包括DNA甲基化和基因素修饰.
  • 该领域面临着标准化和机制性解释方面的挑战.

结论:

  • 表观遗传学是一个重要的领域,对健康和疾病有重大影响.
  • 需要进一步的研究才能充分阐明复杂的表观遗传调节.
  • 跨学科的方法对于未来的表观遗传学发现至关重要.