氨酸激酶受体RET是皮耶尔补丁器官生成的关键调节器
Henrique Veiga-Fernandes1, Mark C Coles, Katie E Foster
1Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Nature
|February 27, 2007
概括
RET信号通路对于肠道中佩耶斑块的形成至关重要. 这一途径调节神经和淋巴系统,在胚胎发育期间协调肠道器官生成.
科学领域:
- 发展生物学 发展生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 正常的器官生成依赖于协调的细胞相互作用和组织特异性因素.
- 淋巴细胞细胞生成在胚胎发育过程中涉及严格调节的分子表达.
- 造血细胞和 stromal 细胞相互作用形成淋巴体器官.
研究的目的:
- 研究控制肠道皮耶斑块形成的分子机制.
- 确定关键的信号通路,参与肠关联淋巴组织的发展.
- 探索RET信号通路在Peyer补丁器官生成中的作用.
主要方法:
- 分析肠道中血液形成细胞的运动性.
- 特定的血液形成细胞群体的特征 (CD45+CD4-CD3-Il7Ralpha-c-Kit+CD11c+).
- 对RET信号和Gfra3缺陷的功能遗传分析.
主要成果:
- 在皮耶尔补丁聚合之前,肠道造血细胞表现出随机运动性.
- 一个特定的表达淋巴毒素和RET的造血细胞群对于皮耶尔斑块的形成至关重要.
- RET信号和RET/GFRalpha3/ARTN轴对于Peyer补丁的开发至关重要.
- ARTN作为肠道血液细胞的化学吸引剂,诱导宫外皮耶尔贴片状结构.
结论:
- RET信号通路在皮耶尔斑块形成中起着至关重要的作用.
- 这一途径参与了肠道神经系统和肠关联淋巴组织的发展.
- RET信号传递是肠道器官生成分子编排中的关键调节器.
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