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Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
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在溶液中,固态中和Hsp90结合部位上的联结体构成之间的关系:凝丹胺素和放射性

Pahk Thepchatri1, Tomasso Eliseo, Daniel O Cicero

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.

Journal of the American Chemical Society
|February 28, 2007
PubMed
概括

了解溶液中的分子灵活性如何影响药物结合至关重要. 这项研究表明,溶液形状准确地预测了热冲击蛋白90 (Hsp90) 抑制剂的药物结合姿势.

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