抗氧化剂补充剂用于初级和二级预防的随机试验中的死亡率:系统性审查和元分析
Goran Bjelakovic1, Dimitrinka Nikolova, Lise Lotte Gluud
1The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. goranb@junis.ni.ac.yu
JAMA
|March 1, 2007
概括
抗氧化剂补充剂如β-胡卜素,维生素A和维生素E可能会增加死亡风险. 在这次元分析中,维生素C和对死亡率没有显著影响.
科学领域:
- 营养科学 营养科学
- 预防医学 预防医学
- 临床试验 临床试验
背景情况:
- 抗氧化剂补充剂广泛用于疾病预防.
- 关于它们对死亡率的影响的证据仍在争论中.
- 这项研究综合了来自众多随机试验的数据.
研究的目的:
- 评估抗氧化剂补充剂对所有原因死亡率的影响.
- 根据试验偏差和特定补充类型来区分影响.
- 为临床实践提供有关抗氧化剂补充剂的信息.
主要方法:
- 68个随机对照试验的系统综述和元分析.
- 包括涉及β-胡卜素,维生素A,C,E和的试验.
- 用于探索对死亡率的偏差和共变效应的元回归.
主要成果:
- 总的来说,抗氧化剂补充剂对死亡率没有显著影响 (RR,1.02).
- 然而,低偏差风险试验表明死亡率显著增加 (RR,1.05).
- 在低偏差试验中,β-胡卜素,维生素A和维生素E显著增加了死亡率.
结论:
- 补充β-胡卜素,维生素A和维生素E可能会增加死亡风险.
- 维生素C和在死亡率中的作用需要进一步研究.
- 需要仔细考虑抗氧化剂补充剂的使用.
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