Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Carbon Cycle01:14

The Carbon Cycle

Carbon is the basis of all organic matter on Earth, and is recycled through the ecosystem in two primary processes: one in which carbon is exchanged among living organisms, and one in which carbon is cycled over long periods of time through fossilized organic remains, weathering of rocks, and volcanic activity. Human activities, including increased agricultural practices and the burning of fossil fuels, has greatly affected the balance of the natural carbon cycle.
Consecutive Reactions01:22

Consecutive Reactions

Consecutive reactions involve a sequence where the product of a preceding reaction becomes the reactant for the subsequent one. In a simple scheme, A transforms into B, which further reacts to form C, with rate constants k1 and k2, respectively. This concept is evident in the radioactive decay series. Assuming an initial state with only A present, the conservation of matter leads to three coupled differential equations, determining the concentrations of A, B, and C over time.The rate of change...
Reversible or Opposing Reactions01:26

Reversible or Opposing Reactions

Reversible or opposing reactions play a crucial role in understanding the dynamic nature of chemical processes. While kinetics focuses on how reactions proceed, thermodynamics emphasizes that most reactions do not reach completion. Instead, a reverse reaction starts occurring over time, and when its rate equals that of the forward reaction, a dynamic equilibrium is established.For example, consider a simple chemical process where A forms B reversibly. The rate constants for the forward and...
Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems01:15

Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems

Oxidative reactions are pivotal in metabolizing numerous compounds, including pharmaceutical drugs. These reactions often occur in carbon-heteroatom systems, such as carbon-nitrogen, carbon-sulfur, and carbon-oxygen.
In carbon-nitrogen systems, aliphatic and aromatic amines can undergo oxidative reactions. Secondary and tertiary amines, like those found in tricyclic antidepressants, can undergo N-dealkylation, a process that involves the oxidation of the alkyl group. In addition, oxidative...
Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
Microbes and the Carbon Cycle01:24

Microbes and the Carbon Cycle

The carbon cycle is a fundamental Earth process involving the transfer of carbon among the biosphere, lithosphere, atmosphere, and hydrosphere. It plays a critical role in regulating the planet’s climate and supporting life by cycling carbon through various chemical forms and reservoirs. Carbon primarily circulates as carbon dioxide (CO₂), representing its oxidized form, while reduced forms such as methane (CH₄) and organic compounds also play essential roles.Microbial activity is central to...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Correction to "The Atroposelective Iodination of 2-Amino-6-arylpyridines Catalyzed by Chiral Disulfonimides Actually Proceeds via Brønsted Base Catalysis: A Combined Experimental, Computational, and Machine-Learning Study".

Journal of the American Chemical Society·2026
Same author

Stereodivergent Construction of <i>trans</i>-Decalin-Based Terpenoids.

Journal of the American Chemical Society·2026
Same author

Highly Catalytic Allylation of Native Carbohydrates in Water with Indium: Kinetic, Mechanistic, and Spectroscopic Studies.

Journal of the American Chemical Society·2026
Same author

The Atroposelective Iodination of 2-Amino-6-arylpyridines Catalyzed by Chiral Disulfonimides Actually Proceeds via Brønsted Base Catalysis: A Combined Experimental, Computational, and Machine-Learning Study.

Journal of the American Chemical Society·2026
Same author

Data-Driven Prediction of Enantioselectivity for the Sharpless Asymmetric Dihydroxylation: Model Development and Experimental Validation.

ACS central science·2025
Same author

Stereodivergent Synthesis of Perhydrobenz[<i>e</i>]indene Terpenoids.

Journal of the American Chemical Society·2025

相关实验视频

Updated: Jul 14, 2026

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids
07:26

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids

Published on: January 26, 2012

顺序的基碳循环/基于的交叉合反应.

Scott E Denmark1, Jack Hung-Chang Liu

  • 1Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA. denmark@scs.uiuc.edu

Journal of the American Chemical Society
|March 6, 2007
PubMed
概括

一种新的催化西碳循环化,其次是催化交叉合,有效地合成了高度替代的环丹. 这种方法可以创建复杂的循环结构,具有出色的控制和广泛的兼容性.

科学领域:

  • 有机化学 有机化学
  • 催化剂是一种催化剂.
  • 合成方法论 合成方法论

背景情况:

  • 环丹支架在天然产品和药品中普遍存在.
  • 高效和多功能合成路径到高度替代的环丹是非常受欢迎的.
  • 现有的方法往往缺乏广泛的基质范围或需要恶劣的条件.

研究的目的:

  • 开发一种新的序列催化策略,用于合成高度替代的环丹.
  • 结合催化西碳循环与催化交叉合.
  • 建立一种具有广泛功能组容忍度的多功能方法.

主要方法:

  • 连续反应,涉及催化1,6-enynes与基二甲基的基碳循环.
  • 使用四-n-丁化对得到的基化基基基化进行催化交叉合.
  • 探索各种替代模式和异质原子的结合.

主要成果:

  • 成功合成了密集功能化的3-(Z) - - 化烯cyclopentanes和异环环.
  • 在温和条件下实现的高收益率和完全保留双重债券配置.
  • 证明了广泛的基质范围,与各种替代模式和异构原子兼容.

更多相关视频

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
13:09

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

Published on: January 4, 2018

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

相关实验视频

Last Updated: Jul 14, 2026

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids
07:26

Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids

Published on: January 26, 2012

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
13:09

Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations

Published on: January 4, 2018

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

结论:

  • 已经建立了一个强大的,高效的循环坦合成序列催化系统.
  • 开发的方法为访问复杂的循环结构提供了一个多功能平台.
  • 这种方法为有机合成和药物发现提供了有价值的工具.