在体外受精的温和治疗策略:一个随机的非劣势性试验
Esther Mew Heijnen1, Marinus Jc Eijkemans2, Cora De Klerk3
1Department of Reproductive Medicine and Gynaecology, University Medical Centre, Utrecht, Netherlands; Division of Reproductive Medicine, Erasmus Medical Centre, Rotterdam, Netherlands.
Lancet (London, England)
|March 6, 2007
概括
温和的体外受精 (IVF) 提供与标准治疗相似的活产率,但显著降低了多胎妊娠和成本. 这种方法减少了患者的不适和财务负担,使试管婴儿更容易获得.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 临床试验 临床试验
背景情况:
- 温和的体外受精 (IVF) 旨在减少与多胎产相关的患者不适和风险.
- 标准的试管婴儿协议通常涉及更积极的刺激和多个胚胎移植.
研究的目的:
- 为了比较轻度试管婴儿与标准试管婴儿在一年内实现活产的有效性.
- 为了评估患者不适,多胎妊娠率和治疗成本的差异.
主要方法:
- 一个随机的,非劣势有效性试验,涉及404名患者.
- 轻度治疗:轻度卵巢刺激用GnRH抗剂和单个胚胎移植.
- 标准治疗:用GnRH激动剂进行长期激发和双重胚胎移植.
主要成果:
- 累积期活产率相似:轻度试管婴儿的43.4%,标准试管婴儿的44.7%.
- 轻度试管婴儿的多胎妊娠率显著降低 (0.5%对13.1%).
- 轻度试管婴儿的平均总成本大幅降低 (8333欧元与10745欧元相比).
结论:
- 轻度试管婴儿治疗显示,在一年内,与标准试管婴儿相比,活产率相当.
- 轻度试管婴儿显著降低了多胎妊娠率和相关成本.
- 患者的不适程度在两个方案之间没有显著差异.
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