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计算机断层扫描查和肺癌结局结果

Peter B Bach¹, James R Jett, Ugo Pastorino

¹Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

|March 8, 2007

概括

低剂量计算机断层扫描 (CT) 的肺癌查增加了诊断和治疗率,但没有显著减少晚期肺癌或死亡. 在广泛实施查之前需要进一步的研究.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

计算机断层扫描 (CT) 的肺癌查正在为吸烟者实施,但对其对结果的影响的证据有限.
随机对照试验正在进行中,以进一步评估CT查疗效.

研究的目的:

为了确定肺癌查是否会增加诊断和切除频率.
评估查是否降低了晚期肺癌诊断或肺癌死亡率的风险.

主要方法:

从1998年开始,对3246名无症状吸烟者进行了纵向分析,这些吸烟者每年接受CT查.
在美国和意大利的学术医疗中心进行了平均3.9年的随访.
观察到的肺癌诊断,切除,晚期病例和死亡与预期值的比较.

主要成果:

肺癌的诊断发生在144人中,而预期为44.5人 (RR, 3.2).
在109名患者中进行了肺癌切除,而预期为10.9名 (RR, 10.0).
没有观察到晚期肺癌诊断 (42 vs 33.4预期) 或肺癌死亡 (38 vs 38.8预期) 的显着减少.

结论:

低剂量CT肺癌查可能会增加诊断和治疗率.
查并没有显著降低晚期肺癌或肺癌相关死亡的风险.
无症状个体只应在临床研究研究中进行查,直到获得最终数据为止.

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