胸痛的变体. 胸痛变体. 冠状动脉在固定冠状动脉阻塞的发展中的作用
J C Kaski1, D Tousoulis, E McFadden
1Cardiovascular Research Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
Circulation
|February 1, 1992
概括
在Prinzmetal的变异性心痛中经常出现的冠状动脉,并不经常导致缩在位的进展. 这项研究发现,尽管随着时间的推移,冠状动脉直径的变化很小,尽管随着时间的推移出现了反复的闭塞.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 干预心脏病学 干预心脏病学
背景情况:
- 假设反复出现的冠状动脉缩有助于固定动脉样硬化阻塞.
- 普林兹金属变异性心痛的特点是动态的,可逆的冠状动脉狭窄.
- 了解对冠状动脉样硬化的长期影响对于患者管理至关重要.
研究的目的:
- 调查复发的焦点冠状动脉是否会导致冠状动脉狭窄症在患有Prinzmetal变异性胸痛的患者中进展.
- 评估冠状动脉直径的变化在可重复性的地点在一个显著的随访期间.
主要方法:
- 一组10名患有活跃Prinzmetal变异性胸痛的患者接受了重复冠状动脉造影.
- 计算机动脉图被用来评估在性和非性冠状动脉段的狭窄进展.
- 冠状动脉直径和狭窄严重程度在初始和随访血管图 (25 +/- 12个月间隔) 之间进行了比较.
主要成果:
- 在10名患者中的9名患者中,发生在先前识别的狭窄部位 (20-65%的直径减少).
- 对于性,非性狭窄或正常非性段的初始和随访动脉图之间没有观察到平均直径的显著差异.
- 狭窄症的进展到完全封闭发生在一个病人在位和两个病人在非位.
结论:
- 在患有慢性Prinzmetal变异性心痛的患者中,重复的焦点冠状动脉,而没有心肌梗塞,并不经常导致缩在位的进展.
- 这些发现表明,冠状动脉可能不是在观察到的时间范围内在这个患者群体中固定动脉硬性病变发展的主要驱动因素.
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