大型心脏病发作中被遗留的上心脏的高电流刺激会诱导心室性心跳动
K M Kavanagh1, J S Kabas, D L Rollins
1Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Circulation
|February 1, 1992
概括
这项研究表明,一种特定的电刺激方案可以通过创建一个数字八重返入路径来诱导心室动脉冲动 (VT) 或心室动 (VF). 组织类型和周期长度决定了VT或VF是否发生,提供了一种研究心律失常的新方法.
科学领域:
- 心血管电生理学 心血管电生理学
- 心脏节律失常研究 心脏节律失常研究
- 心肌梗塞模型的心肌梗塞模型
背景情况:
- 室内动脉短拍 (VT) 和室内动 (VF) 可能源于图8的再进入途径.
- 心律失常的类型 (VT与VF) 取决于组织特征和周期长度,而不仅仅是诱导方法.
- 以前的研究表明,特定的刺激方案可能会影响心律失常的结果.
研究的目的:
- 调查用于VF值确定的协议是否可以在心脏病发作中节省的心肌组织中诱导VT.
- 探索刺激参数,组织性质和持续单态VT与VF诱导之间的关系.
- 建立一种可复制的方法,用于诱导已知的VT研究的图形八重返入路径.
主要方法:
- 使用了一种犬类心肌梗塞模型 (左前下垂冠状动脉封闭-回).
- 从各种心室部位传递S1刺激,然后在心脏上部传递S2刺激.
- 系统地改变S2刺激强度和扩张性合间隔,以减少周期长度,以诱导心律失常.
主要成果:
- 持续的单态图形八形VT被诱导的频率更高 (24个位点),而不是VF (9个位点) (p=0.03).
- 与VF相比,VT表现出较长的平均周期长度 (152 ± 33毫秒) (115 ± 13毫秒) (p<0.001).与VF相比,VT表现出较长的平均周期长度 (152 ± 33毫秒).
- 心脏病转移的程度与心律不整的结果相关;较薄的心脏病偏好静脉引.
结论:
- 在非传输性心脏梗塞上施加大量的S2刺激可以可靠地诱导静脉动脉,如果节省的心肌很薄.
- 这项研究提出了一种新的技术,用于诱导具有可预测的八号图路径方向的持续单态VT.
- 该方法允许通过调整刺激参数和S1位点来控制各种VT形态的诱导.
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