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Updated: Jul 13, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
缺血性心脏的急性冬眠和再输液
1Department of Pathology, Yale University School of Medicine, New Haven, Conn. 06510.
由急性冬眠保护的新生猪心经在长期缺血后显著恢复. 的管理完全逆转了最小的麻醉,保持心脏功能.
科学领域:
- 心脏病学 心脏病学
- 生理学 生理学 生理学
- 生物化学 生物化学
背景情况:
- 在长期低流血缺血后,研究了新生猪心脏的恢复.
- 在受控的实验条件下利用隔离的,同体积跳动的心脏.
研究的目的:
- 评估急性冬眠对新生猪心脏从长期的正常热缺血中恢复的保护作用.
- 评估心肌机械功能,新陈代谢和生化标志物后缺血.
主要方法:
- 隔离的新生猪心脏被输入红细胞增强的克雷布斯-亨赛莱特缓冲器.
- 通过充满液体的气球评估左心室功能;测量包括峰值缩压和压率乘积 (PRP).
- 测量了心肌氧代谢 (MVO2) 和乳酸摄取量;冠状动脉流量 (CF) 减少到10%为2小时,然后再注入.
主要成果:
- 减少CF导致功能 (PRP) 和MVO2的急剧下降,控制的20%,在缺血期间释放乳酸.
- 渐进性CF恢复与增加的机械功能和新陈代谢相关.
- 在30分钟的再注血后,PRP为对照组的78% (p=0.05),+dP/dtmax没有差异;ATP和肌酸水平相同.
结论:
- 急性冬眠保护体外心脏免受长期的正常热缺血.
- 缩功能仅略有下降,速度 (+dP/dtmax) 与对照组相比仍然相当.
- 观察到的最小心肌震荡是完全可逆的与的管理.
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