高动脉氧张力对功能,血液流量分布和缺血性心肌中代谢的影响
B A Cason1, J A Wisneski, R A Neese
1Department of Anesthesiology, University of California, San Francisco.
Circulation
|February 1, 1992
概括
高水平的氧气可以在缺血期间改善心脏功能. 动脉高氧增强了区域心肌收缩功能和血液流动,同时减少了缺血性心肌中的糖性代谢.
科学领域:
- 心脏病学 心脏病学
- 身体生理学 身体生理学
- 生物化学 生物化学
背景情况:
- 氧气吸入疗法用于急性心肌缺血症,但其在没有低氧症的情况下的益处仍在争论中.
- 这项研究研究了动脉过氧对猪模型中心肌缺血的影响.
研究的目的:
- 为了确定动脉过氧对区域性心肌收缩功能,血液流量分布和急性低流量心肌缺血期间的糖分代谢的影响.
- 评估高血脉氧水平是否能改善缺血病患者的心脏功能和代谢状况.
主要方法:
- 猪模型的子内心肌动脉缺血被使用,控制左前下垂冠状动脉流量.
- 通过启发氧度 (FIO2) 操纵动脉氧的部分压力 (PO2).
- 区域性心肌功能 (声微观测),血流 (微球) 和新陈代谢 (碳同位素标记基质) 在正常和高氧状态下被测量.
主要成果:
- 心肌缺血减少了缩缩和内心血流.
- 冠状动脉过氧显著增加了缺血区缩和内心血管血流.
- 过氧改善了内心:表心流量比,并在缺血性心肌中降低了葡萄糖吸收和乳酸生产.
结论:
- 在急性低流动心肌缺血期间动脉PO2升高改善心肌功能和血液流量分布.
- 高水平的氧气会降低缺血性心肌中的甘油性代谢.
- 观察到的收缩功能的改善与心下内脏血流的增强相关.
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