阿尔戈诺和公司:逆风航行
Suvendra N Bhattacharyya1, Witold Filipowicz
1Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.
Cell
|March 27, 2007
概括
蛋白质AGO2和FXR1与TNFalpha mRNA的3'-未翻译区域结合. 这种结合意外地激活了mRNA翻译,这个过程取决于细胞生长.
科学领域:
- 分子生物学分子生物学
- 后转录法规 后转录法规 后转录法规
- 基因表达 基因表达
背景情况:
- 在转录后,mRNA的3未翻译区域 (UTR) 在调节基因表达方面发挥着至关重要的作用.
- 已知蛋白质AGO2和FXR1参与微RNA调节和翻译抑制.
研究的目的:
- 研究AGO2和FXR1在转录后调节中的新功能.
- 阐明AGO2和FXR1影响mRNA翻译的机制.
主要方法:
- 蛋白质-RNA相互作用的分析.
- 对mRNA翻译调节的研究.
- 细胞生长依赖的测试.
主要成果:
- 发现AGO2和FXR1与TNFalpha mRNA的3-UTR中的富含AU元素结合.
- 这种结合事件出乎意料地导致TNFalpha mRNA翻译的激活.
- 翻译的激活取决于细胞的生长阶段.
结论:
- 在激活mRNA翻译方面,AGO2和FXR1具有以前未知的功能.
- AGO2和FXR1与TNFalpha mRNA的3-UTR的相互作用为控制基因表达提供了一个新的机制.
- 细胞生长影响了AGO2和FXR1在翻译中的调节作用.
相关概念视频
Archimedes' Principle
9.6K
Archimedes' principle states that an upward buoyant force exerted on a body that is immersed partially or entirely in a fluid is equal to the weight of the fluid displaced by it. To understand how much buoyant force is needed to make an object float, let us think about what happens when a submerged object is removed from a fluid. If the object were not in the fluid, the space occupied by the object would be filled by the fluid having a weight wfl. This weight is supported by the...
9.6K
Tidal Forces
2.9K
The origin of Earth's ocean tides has been a subject of continuous investigation for over 2000 years. However, the work of Newton is considered to be the beginning of the proper understanding of the phenomenon. Ocean tides are the result of gravitational tidal forces. These same tidal forces are present in any astronomical body; they are responsible for the internal heat that creates the volcanic activity on Io, one of Jupiter's moons, and the breakup of stars that get too close to...
2.9K
Standing Waves
4.3K
Sometimes waves do not seem to move; rather, they just vibrate in place. Unmoving waves can be seen on the surface of a glass of milk kept in a refrigerator, which is one example of standing waves. Vibrations from the refrigerator motor create waves on the milk that oscillate up and down but do not seem to move across the surface. These waves are formed or created by the superposition of two or more identical moving waves in opposite directions. The waves move through each other, with their...
4.3K
Coriolis Force
7.7K
An accelerating particle experiences a force equal to the mass multiplied by the acceleration in an inertial frame of reference. Consider a particle in a non-inertial frame of reference, such as a sliding ball on a rotating table. The acceleration of the ball in this rotating reference frame is different than in the intertial frame, which modifies its equation of motion. The fictitious forces acting additionally on a rotating frame of reference alter Newton's Second Law expression.
7.7K
Angular Momentum
1.0K
Angular momentum characterizes an object's rotational motion and is defined as the moment of its linear momentum about a specified point O. When a particle moves along a curved path in the x-y plane, the scalar formulation calculates the magnitude of its angular momentum, utilizing the moment arm (d), representing the perpendicular distance from point O to the line of action of the linear momentum. Despite being scalar in formulation, angular momentum is inherently a vector quantity. Its...
1.0K
Azimuths and Bearings
1.1K
Azimuths and bearings are essential concepts in surveying, providing methods to express the direction of a line relative to a meridian. Azimuths refer to the clockwise angle measured from the north end of a reference meridian to the given line, ranging from zero to 360 degrees. This method gives a comprehensive directional reference within a full 360-degree circle, making it a straightforward way to communicate direction in various fields, including navigation, cartography, and...
1.1K


