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Updated: Jan 9, 2026

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一个强效和选择性的PPAR-α激动剂在患有动脉动脉性失脂症或高胆固醇血症的患者的影响:两个随机对照试验

Steven E Nissen1, Stephen J Nicholls, Kathy Wolski

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA. nissens@ccf.org

JAMA
|March 27, 2007
PubMed
概括

LY518674,一种强大的PPAR-alpha激动剂,有效降低了三甘油,并在患有脱脂症和高胆固醇症的患者中提高了HDL-C. 然而,它也增加了LDL-C和血清肌素,引发了类似于费诺纤维酸盐的安全问题.

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