中央同情驱动和磁共振成像测定在基本高血压中左心室质量的关系
Joanna Burns1, Mohan U Sivananthan, Stephen G Ball
1Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Circulation
|March 29, 2007
概括
交感神经活动与高血压中的左心室缩 (LVH) 有关. 增加的交感激活与较大的左心室质量 (LVM) 相对应,支持其在LVH发展中的作用.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 神经心脏病学 神经心脏病学
背景情况:
- 交感神经系统过度活跃是左心室缩 (LVH) 发展的已知因素.
- 交感激活和左心室质量 (LVM) 在不同动脉压力之间之间的确切关系尚不清楚.
- 这项研究研究了同情活动和LVM在患有和没有LVH的高血压个体之间的联系.
研究的目的:
- 在高血压患者中确定交感激活和左心室质量 (LVM) 之间的关系.
- 为了比较同情神经活动和LVM在患有和没有LVH的患者与正常对照.
- 评估同情活动,LVM和动脉血压之间的相关性.
主要方法:
- 与24名没有LVH (LVH[-]) 的高血压患者进行比较,25名患有LVH (LVH[+]),24名对照患者.
- 使用多单元和单元记录量化静止肌肉交感神经活动 (SNA).
- 通过心磁共振成像测量左心室质量 (LVM),与身体表面积 (LVM指数) 进行索引.
主要成果:
- 在LVH[+] (91g/m2) 中,LVM指数明显高于LVH[-] (67g/m2) 和对照组 (57g/m2).
- 与对照组相比,同情活动在LVH[-] (53次/100次) 和LVH[+] (66次/100次) 中较高 (39次/100次).
- 在高血压组中,在SNA和LVM指数之间发现了强烈的正相关性 (r=0.76),但不是对照组. 没有观察到一致的BP-SNA或BP-LVM关系.
结论:
- 中心交感激活与人类高血压中左心室缩 (LVH) 相关.
- 这些发现强化了同情性过度活跃在LVH病变发生过程中的作用.
- 在这种情况下,仅靠动脉压并不能始终预测同情活动或LVM.
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