相关实验视频
Updated: May 5, 2026
01:22
Bone Marrow Sampling and Transplants
846
通过磁共振成像来确定心脏梗塞组织异质性,在患有左心室功能障碍的患者中发现心律不整的易感性增加
André Schmidt1, Clerio F Azevedo, Alan Cheng
1Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Circulation
|March 29, 2007
概括
通过MRI测量心肌梗塞组织异质性,强烈预测心脏功能障碍患者的腹腔动脉障碍诱导性. 这一发现突显了异质性作为心律失常发作后易感性的一个关键因素.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 电子生理学 电子生理学
背景情况:
- 在MRI上,心脏外发作区域的延伸与冠状动脉疾病的死亡率相关.
- 心脏病边界中的心律失常是一种潜在的机制.
- 心脏病外围组织异质性和心律失常基质之间的联系尚未被探索.
研究的目的:
- 用对比度增强的MRI量化心肌梗塞异质性.
- 为了将心脏病发作异质性与心律失常基质的电生理学标志物相关联.
- 为了研究患有左心室 (LV) 缩功能障碍的患者,接受预防性植入式心脏转换器除器安置.
主要方法:
- 47名患者在植入可移植心脏转换器除器植入之前接受了电影和对比增强的MRI.
- 一种新的方法量化了异质性心脏病外围和密集心脏病核心.
- 核磁共振成像指数与持续的单形心室动脉动心率诱导性相关.
主要成果:
- 在可诱导和非可诱导组之间,LV喷射分数,终端透析体积和心脏病发作大小是相似的.
- 在心脏病发作外围组织异质性的量化与心室动脉动脉障诱导性强烈相关 (P=0.015).
- 心脏病外围组织异质性是后勤回归的唯一重要因素.
结论:
- 在人类心肌梗塞中,组织异质性是可量化的.
- 较大的组织异质性与心室刺激性增加有关.
- 解剖组织异质性增加了患有心肌梗塞和LV功能障碍的患者对心室节律失常的敏感性.
相关概念视频
Magnetic Resonance Imaging
7.6K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.6K
Mechanism of Cardiac Arrhythmias
2.8K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.8K
Myocarditis I: Introduction
647
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
647
Dysrhythmias V: Evaluating Dysrhythmias
428
Dysrhythmias, also known as arrhythmias, are disturbances in the heart's rhythm that range from benign to life-threatening. A thorough evaluation is crucial for appropriate management and involves a comprehensive medical history, physical examination, and various diagnostic tests.Medical HistorySymptoms: Collect detailed information on palpitations, dizziness, syncope, chest pain, and fatigue. Note their onset, frequency, and triggers.Previous Cardiac Issues: Document any history of heart...
428
Cardiomyopathy III: Hypertrophic Cardiomyopathy
810
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
810