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脑卒中和过时性缺血性发作的二次预防:更多的血小板抑制是答案吗?
1Cardiovascular Division, Department of Medicine, Brigham & Women's Hospital, 65 Landsdowne St, Rm 275, Cambridge, MA 02139, USA. jliao@rics.bwh.harvard.edu
Circulation
|March 29, 2007
概括
二次性中风预防至关重要,因为心脏病的双重抗血小板治疗不能预防复发性中风. 组合疗法提供最佳的血小板抑制,用于二次中风保护.
科学领域:
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 经常性脑血管事件占美国每年中风的很大一部分.
- 二次性中风预防是患者中风或过渡性缺血性发作 (TIA) 病史的关键管理目标.
研究的目的:
- 评估抗血小板疗法的有效性和安全性,以预防二次中风.
- 确定缺血性中风患者的最佳抗血小板策略.
主要方法:
- 对中风患者抗血小板治疗的最近临床试验的综述.
- 在脑血管疾病和心血管疾病中抗血小板疗效的比较.
主要成果:
- 对冠状动脉综合征有益的双重抗血小板治疗不能提供二次中风保护.
- 由于不同的病因和出血风险,中风患者可能需要不同的抗血小板治疗方案.
- 预防中风的最佳血小板抑制需要保持平衡,以避免增加出血.
结论:
- 缺血性中风的抗血小板治疗应优先考虑对心肌保护的二次中风保护.
- 组合疗法可能通过优化血小板抑制和血管保护来提供二次中风保护的最佳策略.
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