假牙内心炎的当代临床形象和结果
Andrew Wang1, Eugene Athan, Paul A Pappas
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. a.wang@duke.edu
JAMA
|March 30, 2007
概括
假内心炎 (PVE) 是一个严重的问题,金黄色葡萄球菌是主要的原因. 医疗保健相关的感染和PVE并发症强烈预测高在医院死亡率.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 假内心炎 (PVE) 呈现出显著的死亡率和发病率.
- 关于PVE的临床概况和结果的当代数据有限.
研究的目的:
- 确定PVE的患病率,临床特征和结果.
- 调查与医疗保健相关的感染对PVE的影响.
- 确定PVE患者住院死亡率的预后因素.
主要方法:
- 一项前性,观察性队列研究,涉及556名确定的PVE患者.
- 在28个国家的61个医疗中心收集的数据 (内分心炎前性队列研究国际合作,2000-2005年).
- 测量的主要结果是住院死亡率.
主要成果:
- 在感染性内心炎病例中,PVE占20.1%.
- 金黄色葡萄球菌是最常见的病原体 (23.0%),其次是凝结酶负型葡萄球菌 (16.9%).
- 与医疗保健相关的PVE发生在36.5%的病例中,通常发生在植入后的第一年内.
- 住院死亡率为22.8%,预测年龄较大,与医疗保健相关的感染,黄金色杆菌,心力衰竭,中风,,和细菌血症.
结论:
- 在全球范围内,PVE占感染性内心炎病例的很大一部分.
- 黄金葡萄球菌是PVE的主要原因.
- 与医疗保健相关的感染和PVE并发症显著影响患者的治疗结果和死亡率.
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