Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

252
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
252
Cancer Vaccines01:30

Cancer Vaccines

917
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
917
Development of Immunocompetence01:22

Development of Immunocompetence

759
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
759
Vaccinations01:51

Vaccinations

51.1K
Overview
51.1K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.5K
Teratogenicity01:07

Teratogenicity

3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Transcriptional and chromatin dynamics in macrophage differentiation and activation.

Science immunology·2026
Same author

SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway.

bioRxiv : the preprint server for biology·2026
Same author

Stress-Induced <i>PTBP1</i> Reprograms Neuronal Function and Activates Cellular Senescence.

bioRxiv : the preprint server for biology·2026
Same author

Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model.

Blood·2026
Same author

Macrophage sensing of the acidic milieu: BRD4 condensates in focus.

Life metabolism·2026
Same author

Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.

Journal of hepatology·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
查看所有相关文章

相关实验视频

Updated: Jan 6, 2026

Mitral Valve Prolapse III: Nursing Management
01:19

Mitral Valve Prolapse III: Nursing Management

Published on: June 19, 2025

252

对立的LSD1复合体在发育基因激活和抑制程序中起作用.

Jianxun Wang1, Kathleen Scully, Xiaoyan Zhu

  • 1Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA.

Nature
|March 30, 2007
PubMed
概括
此摘要是机器生成的。

基因组脱甲基酶LSD1在垂体发育过程中调节基因激活和抑制. 它的复合体受到ZEB1的影响,调节器官中的细胞分化和时间基因表达模式.

更多相关视频

Cancer Vaccines
01:30

Cancer Vaccines

917
Development of Immunocompetence
01:22

Development of Immunocompetence

759

相关实验视频

Last Updated: Jan 6, 2026

Mitral Valve Prolapse III: Nursing Management
01:19

Mitral Valve Prolapse III: Nursing Management

Published on: June 19, 2025

252
Cancer Vaccines
01:30

Cancer Vaccines

917
Development of Immunocompetence
01:22

Development of Immunocompetence

759

科学领域:

  • 表观遗传学和发育生物学
  • 基因调节的分子机制

背景情况:

  • 甲动物发育中的转录控制依赖于协调复合体和表观遗传修饰.
  • 基因组甲基转移酶和脱甲基酶在编排不同的发育基因程序中的精确的体内作用仍然不清楚.

研究的目的:

  • 为了研究氨酸脱甲基酶LSD1在垂体器官生成中的作用.
  • 阐明LSD1如何在晚期细胞系确定和分化过程中调节基因激活和抑制程序.

主要方法:

  • 研究了LSD1的功能,这是CoREST-CtBP联合抑制器综合体的一个组成部分.
  • 调查了LSD1招募不同的协同激活剂或协同抑制剂复合物.
  • 研究了ZEB1表达对LSD1依赖基因抑制的影响.

主要成果:

  • 在垂体腺体中,LSD1对于晚期细胞系确定和分化至关重要.
  • LSD1通过不同的复杂结构来调节基因激活和抑制程序.
  • 在发育晚期诱导的ZEB1表达会招募含有LSD1的复合体来抑制额外的基因,包括Gh.

结论:

  • LSD1复合元件的时间表达模式在哺乳动物器官发育过程中调节基因调节程序.
  • LSD1在垂体器官生成中起着动态的作用,在激活和抑制功能之间切换.
  • 在后来的发育阶段,ZEB1充当扩展LSD1介导基因抑制的关键调节者.