Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K
Antigen Presenting Cells01:22

Antigen Presenting Cells

3.7K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.7K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.9K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Immune signatures underlying post-acute COVID-19 lung sequelae.

Science immunology·2021
Same author

Pathways to post-traumatic growth in cancer patients: moderated mediation and single mediation analyses with resilience, personality, and coping strategies.

Journal of affective disorders·2020
Same author

An effective CTL peptide vaccine for Ebola Zaire Based on Survivors' CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design.

Vaccine·2020
Same author

Enhanced bud regeneration in aspen (Populus tremula L.) roots cultured in liquid media.

Plant cell reports·2019
Same author

Ovarian cancer in Manitoba: trends in incidence and survival, 1992-2011.

Current oncology (Toronto, Ont.)·2017
Same author

Cripto-1 vaccination elicits protective immunity against metastatic melanoma.

Oncoimmunology·2016

相关实验视频

Updated: May 5, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

12.4K

抗原模拟-主要基因相容性复合体作为T细胞受体的对手.

M T De Magistris1, J Alexander, M Coggeshall

  • 1Cytel, San Diego, California 92121.

Cell
|February 21, 1992
PubMed
概括
此摘要是机器生成的。

研究人员发现了一种新的方法来抑制T细胞反应,使用非刺激性类类似物. 这些类似物通过与T细胞受体结合来阻断特定的T细胞反应,为免疫调节提供了一种新的方法.

更多相关视频

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

12.4K
Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

10.9K

相关实验视频

Last Updated: May 5, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

12.4K
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

12.4K
Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

10.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 对于适应性免疫,T细胞的反应至关重要.
  • 失调的T细胞活动是许多自身免疫和炎症性疾病的基础.
  • 了解T细胞抑制机制是治疗开发的关键.

研究的目的:

  • 阐明一种抑制T细胞反应的新机制.
  • 调查非刺激性类型在调节T细胞活性中的作用.
  • 探索T细胞介导免疫的抗原特异性抑制.

主要方法:

  • 使用的流感血凝素 (HA) 307-319和DR1II类主要基因相容性复合体 (MHC) 分子.
  • 使用非刺激性HA类类似物进行抗原呈现抑制测试.
  • 进行了直接结合和细胞实验,以确定作用机制.
  • 使用毒素830-843测试了该效应的概括性.

主要成果:

  • 作为HA的非刺激类型,它优先抑制HA特异性T细胞.
  • 观察到的抗原特异性抑制也与另一种DR1-受限有效.
  • 该机制与DR1结合,负信号或T细胞耐受性诱导的竞争有所区别.
  • 有证据表明,T细胞受体 (TCR) 参与的竞争性阻断.

结论:

  • 一种新的T细胞抑制机制涉及DR1-类型模拟复合体,参与抗原特异性T细胞受体.
  • 这种参与导致抗原特异性T细胞反应的竞争性阻断.
  • 这些发现为调节T细胞免疫提供了新的策略.