颗粒细胞殖民地刺激因子和颗粒细胞巨细胞殖民地刺激因子在无脂蛋白E缺乏的小鼠中加剧了动脉样硬化
Amir Haghighat1, Daiana Weiss, Matthew K Whalin
1Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA.
Circulation
|April 4, 2007
概括
在动脉样硬化小鼠模型中,花细胞殖民地刺激因子 (G-CSF) 和花细胞巨细胞殖民地刺激因子 (GM-CSF) 没有改善血管修复. 相反,这些生长因子加剧了动脉样硬化病变的程度,增加了随机血管性.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 来自骨髓的原始细胞可能有助于血管修复.
- 用花细胞殖民地刺激因子 (G-CSF) 和花细胞巨细胞殖民地刺激因子 (GM-CSF) 调动原生细胞已被探索用于血管修复.
- 短期使用G-CSF或GM-CSF对动脉样硬化的影响尚不清楚.
研究的目的:
- 研究G-CSF和GM-CSF对动脉样硬化的治疗作用.
- 为了确定G-CSF或GM-CSF的管理是否会影响小鼠模型中的动脉样硬化病变的发展.
主要方法:
- 缺乏阿波利波蛋白E的小鼠接受了8周的G-CSF或GM-CSF (10微克 x 千克(-1) x d(-1) s.c.) 治疗.
- 在整个治疗期间,小鼠一直吃高脂肪饮食.
- 评估了动脉样硬化病变的程度,炎症细胞透和基因表达.
主要成果:
- 无论是G-CSF还是GM-CSF治疗都导致动脉样硬化病变程度的增加.
- 没有观察到炎症细胞或促炎性基因表达的显著增加.
- 突发性血管性显著增加,这表明vasa vasorum的新血管化.
结论:
- 在这种动脉样硬化模型中,G-CSF和GM-CSF的管理未能显示出有益的影响.
- 无论是G-CSF还是GM-CSF都导致动脉样硬化的恶化.
- 血管新血管化可能在观察到的动脉样硬化的恶化中起作用.
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