冠状动脉附带资金在皮肤间干预后仍然可以招募
Divaka Perera1, Gajen S Kanaganayagam, Mrinal Saha
1Cardiovascular Division, Rayne Institute, St Thomas' Hospital Campus, King's College, London, UK.
Circulation
|April 4, 2007
概括
冠状动脉担保流在PCI后24小时保持稳定,但在6个月内显著下降. 循环干细胞与干预后的附带功能相关.
科学领域:
- 心血管研究研究心血管研究
- 干预心脏病学 干预心脏病学
- 血管生物学 血管生物学
背景情况:
- 穿皮冠状动脉干预 (PCI) 可以导致快速失去附带支持,增加心肌梗塞风险.
- 发达的冠状动脉附带体即使没有缺血性刺激也存在,这表明固有的可塑性.
- 了解PCI后的附带供应动态对于管理心肌输液至关重要.
研究的目的:
- 评估PCI后冠状动脉附带供应的可塑性和决定因素.
- 为了评估PCI之后的时间内抵押品流量指数 (CFI) 的变化.
- 识别影响附带功能的因素,包括病变特征和循环的血液细胞.
主要方法:
- 使用压力测量计算的附带流量指数 (CFI) (大动脉,中央静脉,冠状动脉).
- 在60名患者成功进行PCI后,基线时测量CFI,5分钟,24小时和6个月.
- 评估了CFI,冠状动脉损伤严重程度和循环中的CD133+和CD34+细胞之间的关系.
主要成果:
- 在PCI之后的5分钟和24小时内,CFI保持不变.
- CFI显著下降了6个月,占基线值的63% (P<0.001).
- 基线CFI与病变严重程度相关,但这种联系在6个月后消失了. 循环中的CD133+和CD34+细胞与6个月CFI相关联.
结论:
- 在成功进行PCI后,冠状动脉附带流至少维持24小时.
- 功能性抵押支持在PCI后6个月显著减少,但并没有完全回归.
- 循环造血干细胞可能在PCI后长期维持附带功能方面发挥作用.
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