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Nanomanipulation of Single RNA Molecules by Optical Tweezers
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使用在纳米间隙中导电聚合物纳米线的目标引导形成检测MicroRNAs

Yi Fan1, Xiantong Chen, Alastair D Trigg

  • 1Institute of Microelectronics, 11 Science Park Road, Singapore 117685, Republic of Singapore.

Journal of the American Chemical Society
|April 7, 2007
PubMed
概括

这项研究提出了一种新型的生物传感器阵列,用于高度敏感的微RNA (miRNA) 的电检测. 这种创新的设计利用导电聚合物纳米线进行癌症细胞系中目标miRNA的超敏感量化.

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相关概念视频

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...