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相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

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运动中的发展:助手T细胞在工作中

Steven L Reiner1

  • 1Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sreiner@mail.med.upenn.edu <sreiner@mail.med.upenn.edu>

Cell
|April 10, 2007
PubMed
概括
此摘要是机器生成的。

辅助T细胞 (T-辅助细胞) 对于免疫力至关重要,但可以导致自身免疫性疾病. 新的发现,如Th17细胞系,为了解免疫反应及其调节增加了复杂性.

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
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Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

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相关实验视频

Last Updated: May 6, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • 辅助T细胞对于协调哺乳动物对病原体的免疫防御至关重要.
  • 功能障碍的辅助T细胞有助于自身免疫和过敏性疾病.
  • 发现新的T-辅助细胞系,如Th17,突出了免疫调节的复杂性.

研究的目的:

  • 探索辅助T细胞在免疫和自身免疫中的复杂作用.
  • 了解信号和转录网络如何影响T辅助细胞命运.
  • 重新评估适当和不适当的免疫反应的产生.

主要方法:

  • 关于T细胞分化和功能的最新发现的综述.
  • 对参与T-辅助细胞命运决定的信号通路的分析.
  • 检查控制免疫反应的转录网络.

主要成果:

  • 辅助T细胞在防御和自身免疫中起着双重作用.
  • Th17血统代表了已知的T辅助细胞多样性的显著增加.
  • 信号和转录网络是免疫结果的关键决定因素.

结论:

  • 了解T-辅助细胞的可塑性对于管理免疫相关疾病至关重要.
  • 最近的发现正在重塑免疫调节的概念框架.
  • 对T细胞网络的进一步研究将揭示健康和疾病的机制.