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Updated: Jul 15, 2026

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
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Published on: May 5, 2020

强大的Piwis捍卫了生殖线对基因组入侵者

Kathryn A O'Donnell1, Jef D Boeke

  • 1Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Cell
|April 10, 2007
PubMed
概括

皮维蛋白对生殖线基因组完整性至关重要,它通过调节小RNA (piRNA) 和沉默转子来调节基因组完整性. 鼠标Piwi同源Miwi2的丢失会导致生殖线缺陷和转体子活性增加,这表明功能得到保护.

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