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相关概念视频

Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Positive Regulator Molecules02:39

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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相关实验视频

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Analysis of Multidimensional Microscopy Data Using Cell-ACDC
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哺乳动物Golgi通过在线分裂期间释放ACBD3来调节非对称细胞分裂中的麻木信号.

Yan Zhou1, Joshua B Atkins, Santiago B Rompani

  • 1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Cell
|April 10, 2007
PubMed
概括

ACBD3与Numb合作,在哺乳动物神经前体细胞分裂过程中调节细胞命运. 这种相互作用,在线粒分裂期间的戈尔吉分裂的影响下,确保了适当的自我更新和神经元分化.

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科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 发展生物学 发展生物学

背景情况:

  • 哺乳动物神经原生细胞不对称地分裂,分离Numb蛋白来确定子细胞的命运.
  • 矛盾的是,Numb信号明确了祖先的命运,同时也促进了神经元的分化.

研究的目的:

  • 为了确定Numb的新合作伙伴,参与神经发生过程中细胞酸盐规范.
  • 阐明ACBD3在神经母细胞分裂和分化的Numb介导调节中的作用.

主要方法:

  • 蛋白质相互作用研究以确定Numb合作伙伴.
  • 在细胞周期期间对ACBD3亚细胞局部化的分析.
  • 对ACBD3和Numb功能损失和功能增益突变小鼠的表型分析.

主要成果:

  • 鉴定出ACBD3是一种对Numb相互作用的蛋白质,对细胞酸盐规范至关重要.
  • 在分化过程中,ACBD3的局部化从戈尔吉转移到细胞质,在戈尔吉分裂后.
  • 细胞质ACBD3与Numb协同作用,以指定细胞命运,而其持续存在则抑制神经元的产生.

结论:

  • ACBD3是Numb的关键合作伙伴,可以确定前代细胞与神经元细胞的命运.
  • ACBD3的差异性亚细胞分布,在线粒分裂期间由戈尔吉动力学调节,将细胞酸盐特征与细胞周期进展相结合.