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蛋白质设计:重新设计细胞视网膜酸结合蛋白II,将其转化为罗多素蛋白模仿物

Chrysoula Vasileiou1, Soheila Vaezeslami, Rachael M Crist

  • 1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.

Journal of the American Chemical Society
|April 24, 2007
PubMed
概括

研究人员设计了一种细胞视网膜酸结合蛋白II (CRABPII) 突变体,以结合视网膜作为质子化希夫基. 这种仿生方法成功地产生了纳米分子结合剂,揭示了关键的结构见解.

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