Zfx:在生存和自我更新的十字路口
1Laboratory of Molecular Genetics of Stem Cells, Institute for Research in Immunology and Cancer (IRIC), C.P. 6128 succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.
Cell
|April 24, 2007
概括
转录因子Zfx在维持胚胎干细胞和造血干细胞方面发挥着共同的作用. 这一发现揭示了在不同细胞类型中自我更新的共同调节器.
科学领域:
- 干细胞生物学 干细胞生物学
- 细胞命运决定的分子机制
- 血液形成 血液形成 血液形成
背景情况:
- 了解干细胞命运的分子基础对于再生医学和发育生物学至关重要.
- 胚胎干细胞 (ESC) 和造血干细胞 (HSC) 是具有明显自我更新和分化途径的关键细胞类型.
- 识别共享的调节器可以提供对保存干细胞维护机制的基本见解.
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