针对2 - 基托 - 3 - 脱氧 - 6 - 斯 Galactonate Aldolase的进化,以取代3 - 脱氧 - D - 阿拉比诺 - 赫普图酸7 - 酸合成酶

Ningqing Ran1, John W Frost

  • 1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.

概括

定向进化改善了2-keto-3-deoxy-6-phosphogalactonate (KDPGal) 尔多酶,用于微生物生产什基酸盐路产物. 这种工程酶增强了来自大肠杆菌中的葡萄糖的3-脱基胺酸合成.

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