在米托米辛生物合成中的基诺O甲基化

Sabine Grüschow1, Leng-Chee Chang, Yingqing Mao

  • 1Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

概括

该MmcR甲基转移酶对于通过添加甲基基组来产生米托菌素A和B至关重要. 这一甲基化步骤对于关键化疗药物mitomycin C的生物合成至关重要.

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