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Updated: Jul 14, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

通过microRNA-155调节生殖中心的反应

To-Ha Thai1, Dinis Pedro Calado, Stefano Casola

  • 1CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|April 28, 2007
PubMed
概括

微RNA-155 (miR-155) 对哺乳动物免疫系统至关重要,通过控制细胞因子生产来调节T辅助细胞分化和抗体反应. 这突显了微RNA在哺乳动物发育中的重要作用.

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...