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Updated: Jul 15, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

组织素H3K4脱甲基酶SMCX将REST目标基因与X相关的智力障碍联系起来

Mamta Tahiliani1, Pinchao Mei, Rui Fang

  • 1Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and BCMP, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA.

Nature
|May 1, 2007
PubMed
概括

通过去除H3K4三甲基化,JARID1C/SMCX作为转录抑制剂. 它的损失损害了神经元基因调节,可能导致X相关的精神障碍.

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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
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Epigenetic Regulation

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Heterochromatin

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