周血管巨细胞促进动脉动脉生成,并诱导非脂质蛋白E缺乏小鼠的斑块不稳定
Ilze Bot1, Saskia C A de Jager, Alma Zernecke
1Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, PO Box 9502, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. i.bot@lacdr.leidenuniv.nl
Circulation
|May 2, 2007
概括
巨细胞通过促进斑块生长和不稳定性,显著加剧动脉样硬化. 用cromolyn稳定丸细胞有效地预防了这些不良影响,这表明了心血管疾病的新治疗策略.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 乳腺细胞是关键的免疫细胞,参与过敏和宿主防御反应.
- 肥胖细胞数量增加和周围血管组织的激活表明它在诸如动脉样硬化等心血管疾病中起作用.
研究的目的:
- 为了研究周血管巨细胞在动脉动脉生成和斑块稳定性中的作用.
- 为了确定巨细胞激活是否影响活体内斑块的进展和不稳定.
主要方法:
- 利用无脂蛋白E缺乏的小鼠来模拟动脉样硬化.
- 在斑块进展过程中诱导全身和向的周脉巨细胞激活.
- 给了巨细胞稳定剂cromolyn以评估其治疗潜力.
主要成果:
- 系统性巨细胞激活导致了显著的斑块扩张.
- 向激活增加了斑块内出血,巨细胞亡和血管泄漏.
- 巨细胞激活通过CXCR2 / VLA-4通路促进白细胞的招募.
- 克罗莫林治疗成功抑制了巨细胞激活的所有不良影响.
结论:
- 乳腺细胞在活体中推动斑块的进展和不稳定起着至关重要的作用.
- 乳腺细胞稳定成为预防急性冠状动脉综合征的潜在治疗策略.
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