社区中大动脉硬度增加的截面相关性:弗雷明汉心脏研究
Gary F Mitchell1, Chao-Yu Guo, Emelia J Benjamin
1Cardiovascular Engineering, Inc, 51 Sawyer Rd, Suite 100, Waltham, MA 02453, USA. GaryFMitchell@mindspring.com
Circulation
|May 9, 2007
概括
异常的大动脉硬的患病率随着年龄的增长而急剧上升,特别是在肥胖或糖尿病的情况下. 这种与年龄有关的大动脉硬度增加表明,随着人口的老龄化,疾病负担越来越大.
科学领域:
- 心血管科学 心血管科学
- 衰老研究研究 衰老研究
- 公共卫生 公共卫生
背景情况:
- 大动脉硬度增加与常见的衰老疾病如心脏病,中风和脏病有关.
- 大动脉硬度升高的患病率和促成因素尚未完全理解.
研究的目的:
- 为了确定异常大动脉硬度的患病率和相关性.
- 为了研究年龄,心血管风险因素和大动脉硬之间的关系.
主要方法:
- 评估了Framingham,Offspring和Omni队伍中的动脉脉冲波速度和前向压力波幅.
- 从低风险参考组使用性别特定的第90百分位数定义异常硬度.
- 分析的相关性包括年龄,平均动脉压,BMI,葡萄糖代谢和脂质.
主要成果:
- 观察到有24%至33%的异常大动脉硬的患病率.
- 随着年龄的增长,硬度的患病率显著增加,在70岁以上的个人中达到64-74%.
- 较高的平均动脉压,BMI,血糖受损和脂质异常是异常硬度的关键相关因子.
结论:
- 异常的大动脉硬的患病率随着年龄的增长而急剧增加,尤其是肥胖或糖尿病患者.
- 人口老龄化表明,未来由大动脉硬引起的疾病负担将大幅增加.
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