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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Causative Organism
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Myocarditis III: Medical Management01:14

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在美国退伍军人中患有型肝炎病毒的非霍奇金淋巴瘤和淋巴增殖前体疾病的风险.

Thomas P Giordano1, Louise Henderson, Ola Landgren

  • 1Department of Medicine, Baylor College of Medicine, and the Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Tex 77030, USA. tpg@bcm.tmc.edu

JAMA
|May 10, 2007
PubMed
概括
此摘要是机器生成的。

型肝炎病毒 (HCV) 感染增加了非霍奇金淋巴瘤和沃尔登斯特罗姆巨型球蛋白血症的风险. 这项研究支持HCV在引起淋巴增殖和淋巴瘤方面的作用.

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科学领域:

  • 肝病学和病毒瘤学
  • 血液学和恶性瘤研究研究
  • 传染病流行病学 传染病流行病学

背景情况:

  • 肝炎C病毒 (HCV) 感染是肝癌和肝硬化的一个已知原因.
  • 新出现的证据表明,HCV也可能增加其他癌症的风险,包括造血性恶性瘤和甲状腺癌.
  • 之前对这些关联的研究受限于小样本大小.

研究的目的:

  • 调查C型肝炎病毒 (HCV) 感染与血液恶性瘤风险增加之间的关联.
  • 检查HCV感染与相关的淋巴增殖性疾病之间的联系.
  • 评估 HCV 感染个体甲状腺癌的潜在风险增加.

主要方法:

  • 通过使用美国退伍军人事务卫生保健机构 (1997-2004) 的数据进行了回顾性队列研究.
  • 该研究包括146,394名感染HCV的患者和572,293名匹配的未感染HCV的患者.
  • 分析了特定癌症和疾病的风险,并根据各种人口和临床因素进行了调整.

主要成果:

  • 感染HCV与非霍奇金淋巴瘤 (HR,1.28) 的显著增加风险相关,沃尔登斯特罗姆巨型球蛋白血症 (HR,2.76) 和冷球蛋白血症 (HR,3.98).
  • 对于其他血液性恶性瘤,没有观察到显著增加的风险.
  • 虽然甲状腺炎的风险略有增加,但甲状腺癌的风险没有显著增加 (HR,0.72).

结论:

  • 型肝炎病毒感染与20-30%更高的非霍奇金淋巴瘤风险和三倍增加的沃尔登斯特罗姆巨型球蛋白血的风险有关.
  • 在感染HCV的个体中也观察到高血球蛋白血的风险增加.
  • 这些发现支持HCV在淋巴增殖和非霍奇金淋巴瘤的发展中的病因作用.