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与Ha-Ras的致癌和转录合作需要对c-Jun在63和73级蛋白上进行酸化

T Smeal1, B Binetruy, D A Mercola

  • 1Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla 92093-0636.

Nature
|December 12, 1991
PubMed
概括

瘤性Ha-ras信号激活AP-1复合体,通过酸化c-Jun在63和73级蛋白中进行激活. 这种酸化对于Ha-ras诱导的细胞转化和基因表达变化至关重要.

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