低血糖负荷与低脂肪饮食对肥胖年轻人的影响:一项随机试验
Cara B Ebbeling1, Michael M Leidig, Henry A Feldman
1Department of Medicine, Children's Hospital Boston, Boston, Mass 02115, USA.
JAMA
|May 18, 2007
概括
胰岛素分泌会影响减肥的成功在流行饮食中. 低血糖负荷饮食对胰岛素分泌量高的人来说更有效,改善体重和脂肪百分比.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 肥胖问题研究研究
背景情况:
- 对肥胖治疗饮食的临床试验显示了不一致的结果.
- 参与者之间的生理差异可能解释了变化.
- 胰岛素分泌是影响减肥结果的潜在因素.
研究的目的:
- 研究胰岛素分泌对遵循两种流行的饮食的人减肥的影响.
- 为了确定胰岛素反应是否会改变低血糖负载与低脂肪饮食的有效性.
主要方法:
- 一个随机试验,涉及73名肥胖的年轻成年人 (18-35岁).
- 参与者被分配给低血糖负载或低脂肪饮食6个月,随后进行12个月的随访.
- 胰岛素分泌在基线时通过血清胰岛素度在口服葡萄糖剂量后30分钟测量.
主要成果:
- 饮食组之间,总体体重和体脂百分比变化没有差异.
- 胰岛素分泌显著改变了饮食对体重和身体脂肪的影响.
- 低血糖负荷饮食导致更高的胰岛素分泌量 (高于中位数) 的个体体重和体脂减少.
结论:
- 荷尔蒙反应,特别是胰岛素分泌,有助于饮食减肥试验的变化.
- 降低血糖负荷对于高胰岛素分泌量个体的减肥至关重要.
- 低血糖负荷饮食提供心血管益处,改善HDL胆固醇和甘油三,无论胰岛素分泌水平如何.
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