疹病毒的潜伏期赋予了与细菌感染的共生保护
Erik S Barton1, Douglas W White, Jason S Cathelyn
1Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Nature
|May 18, 2007
概括
以前被认为是有害的疹病毒延迟,令人惊的是,它有利于宿主. 潜伏性疹病毒增强先天免疫力,提供对Listeria和Yersinia等细菌感染的抵抗力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 微生物学 微生物学
背景情况:
- 疹病毒在童年感染人类,建立终身潜伏期.
- 延迟通常被视为寄生性,在重新激活时增加疾病风险.
- 疹病毒延迟对宿主免疫的长期影响尚未完全理解.
研究的目的:
- 为了调查疹病毒延迟是否给宿主带来任何好处.
- 确定任何观察到的保护作用背后的机制.
主要方法:
- 小鼠被潜伏感染了小鼠马疹病毒68或小鼠细胞巨乳病毒.
- 感染和对照小鼠随后受到细菌病原体Listeria monocytogenes和Yersinia pestis的挑战.
- 分析了免疫反应,包括细胞因子生产和巨细胞激活.
主要成果:
- 潜在的疹病毒感染使得对Listeria monocytogenes和Yersinia pestis产生了耐药性.
- 保护不是抗原特异性的,并且涉及持续的干扰素玛生产.
- 观察到全身巨细胞激活,这表明一种高调节的先天免疫状态.
结论:
- 疹病毒延迟通过增强对细菌感染的天生的免疫力,提供了显著的免疫益处.
- 延迟可能代表一种共生关系,而不是纯粹的寄生关系.
- 这种延迟诱导的免疫调节可能会影响对其他抗原的反应.
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