影响基因表达的进化能力的遗传特性
Christian R Landry1, Bernardo Lemos, Scott A Rifkin
1Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. clandry@post.harvard.edu
Science (New York, N.Y.)
|May 26, 2007
概括
对突变的基因表达敏感性受到基因结构和TATA盒子存在的影响. 这种敏感性影响了环境变化的可变性和响应,对于理解监管演变至关重要.
科学领域:
- 进化生物学是进化生物学.
- 分子遗传学分子遗传学
- 系统生物学 系统生物学
背景情况:
- 了解基因网络进化是关键.
- 由于与选择,人口统计和突变率的复杂相互作用,仅仅自然变异不足以推断进化模式.
研究的目的:
- 估计自然发生突变对基因表达的影响.
- 在这些估计中尽量减少自然选择的影响.
- 建立基因表达进化的机制基础.
主要方法:
- 估计自然发生的突变对基因表达的影响.
- 在突变效应估计过程中最大限度地减少自然选择的影响.
主要成果:
- 对突变的基因表达敏感性随着转基因突变目标大小的增加而增加.
- 一个TATA盒子的存在增强了对突变的基因表达敏感性.
- 对突变更敏感的基因对环境干扰和随机噪声也表现出更高的敏感性.
结论:
- 对突变的基因表达敏感性与基因结构 (TATA盒) 和大小 (转基因突变目标) 有机联系.
- 这种敏感性是基因对环境因素和噪音反应的预测因素.
- 这些发现为开发监管进化和基因网络进化的现实模型提供了基础.
相关概念视频
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Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
01:42What is Gene Expression?
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
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