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Updated: Jul 14, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

RAP80将BRCA1定位在DNA损伤部位的特定泛素结构上

Bijan Sobhian1, Genze Shao, Dana R Lilli

  • 1Dana-Farber Cancer Institute and Department of Genetics and Department of Medicine, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

Science (New York, N.Y.)
|May 26, 2007
PubMed
概括

研究人员发现BRCA1蛋白如何与DNA损伤部位结合. 在双链断裂 (DSB) 时,RAP80蛋白准BRCA1到无素链,这对于DNA修复和细胞周期检查点至关重要.

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