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相关概念视频

Mismatch Repair01:36

Mismatch Repair

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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相关实验视频

Updated: Jul 11, 2026

A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

重复应变损伤是重复应变损伤.

Maurits van Tulder1, Antti Malmivaara2, Bart Koes3

  • 1Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, Netherlands; Institute of Health Sciences, Faculty of Earth & Life Sciences, VU University, Amsterdam, Netherlands.

Lancet (London, England)
|May 29, 2007
PubMed
概括

重复应变损伤 (RSI) 诊断缺乏可靠的成像证据,有效的治疗主要提供短期的疼痛缓解. 运动对非特定的上肢疾病有好处,而特定的疾病则有针对性的干预措施.

更多相关视频

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

相关实验视频

Last Updated: Jul 11, 2026

A Repetitive Concussive Head Injury Model in Mice
05:42

A Repetitive Concussive Head Injury Model in Mice

Published on: October 12, 2016

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
04:19

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

Published on: June 20, 2017

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

科学领域:

  • 整形外科 整形外科 整形外科
  • 职业医学 职业医学是专业的.
  • 康复医学 康复医学 康复医学

背景情况:

  • 重复应变损伤 (RSI) 包含各种上肢疾病,通常是临床诊断的.
  • 对于RSI诊断的高质量的成像研究 (MRI,超声波) 是有限的,使其作用不清楚.
  • 对上肢疾病治疗有效性的证据很少,主要观察到短期的疼痛缓解.

研究的目的:

  • 审查当前关于诊断和治疗重复性应变损伤的证据.
  • 评估高级成像在诊断上肢疾病中的作用.
  • 评估不同类型RSI的各种干预措施的有效性.

主要方法:

  • 对现有关于重复性应变损伤的文献进行系统审查.
  • 分析诊断准确性研究,包括使用MRI和超声波的研究.
  • 对随机对照试验的评估,以评估上肢疾病的治疗疗效.

主要成果:

  • 临床诊断是RSI的标准,但缺乏高质量的成像证据.
  • 运动对非特异性上肢疾病有益.
  • 特定的治疗方法对诸如手腕道综合征 (支架,手术) 和侧面表皮炎 (NSAIDs,注射) 等疾病显示出有效性.
  • 运动和皮质类固醇注射可能对分别部和肩部疼痛有好处.

结论:

  • 需要进一步进行高质量的试验,重点关注劳动人口和与工作相关的结果.
  • 对重复性应变损伤的干预措施的有效性通常是有限的和短期的.
  • 针对性治疗为特定的上肢疾病提供缓解,但运动对非特定疾病有好处.