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Updated: Jul 10, 2026

A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays
10:44

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Published on: August 26, 2013

矩阵金属蛋白酶的抑制剂指纹使用组合性酸胺库的抑制剂指纹

Mahesh Uttamchandani1, Jun Wang, Junqi Li

  • 1Department of Biological Sciences, National University of Singapore, Singapore 117543.

Journal of the American Chemical Society
|June 2, 2007
PubMed
概括

研究人员使用1400个酸的多样性库绘制了七种矩阵金属蛋白酶 (MMP) 的抑制剂指纹图. 这揭示了独特的抑制模式,有助于选择性药物领先的识别.

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相关概念视频

Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.