运动跑步机测试反应的遗传性,联系性和遗传关联
Erik Ingelsson1, Martin G Larson, Ramachandran S Vasan
1Framingham Study, Framingham, Mass, USA.
Circulation
|June 6, 2007
概括
遗传因素会影响身体对运动的反应,影响血压和心率. 这项研究确定了遗传性,并表明这些关键心血管反应的遗传联系.
科学领域:
- 心血管生理学心血管生理学
- 人类遗传学 人类遗传学
- 运动科学 运动科学
背景情况:
- 运动跑步机测试期间的血压 (BP) 和心率反应是心血管疾病的既定预测因素.
- 这些血液动力学和慢性反应的遗传基础在很大程度上仍未被探索.
研究的目的:
- 为了研究血液动力学和慢性反应对运动的遗传性和遗传联系,进行跑步机测试.
- 为了确定与运动诱导的生理变化潜在的遗传关联.
主要方法:
- 在Framingham Offspring研究中的2982名参与者中,评估了缩血压,腹缩血压和运动和恢复期间的心率.
- 通过差异组件方法估计遗传性,并进行了定量性质联系分析.
- 在14个候选基因中测试了与235个单核酸多态的关联.
主要成果:
- 运动和恢复期间心率的遗传概率估计分别为0.32和0.34.
- 对于炼的继承力 缩和腹缩血压为0.25和0.26,在康复期间降至0.16和0.13.
- 在康复期间发现了缩血压 (1q43-44位置) 和腹缩血压 (4p15.3位置) 的暗示性联系.
结论:
- 对运动的血液动力学和慢性反应表现出显著的遗传性.
- 暗示性遗传联系表明特定的染色体区域影响这些反应.
- 未来的全基因组关联研究可能会揭示运动生理学的新型遗传见解.
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