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Updated: Jun 21, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

五个和六个成员的结构锁定2',4'-碳循环的 ribo-thymidines:合成,结构和生物化学研究

Puneet Srivastava1, Jharna Barman, Wimal Pathmasiri

  • 1Department of Bioorganic Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden.

Journal of the American Chemical Society
|June 8, 2007
PubMed
概括

锁定核酸 (LNA) 和エNA的新碳循环类似物增强了反感性寡核酸的稳定性和治疗潜力. 这些改性寡核酸显示出改善的核酶耐药性和药物动力学特性,用于潜在的药物开发.

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RNA Structure01:23

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Different Types of RNA Have the Same Basic Structure
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