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Updated: Jul 3, 2026

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Akt/PKB通过直接抑制PGC-1α转录协激活剂来调节肝脏代谢

Xinghai Li1, Bobby Monks, Qingyuan Ge

  • 1Institute for Diabetes, Obesity and Metabolism, Cox Institute, University of Pennsylvania School of Medicine and the Howard Hughes Medical Institute, Philadelphia, Pennsylvania 19104, USA.

Nature
|June 8, 2007
PubMed
概括

2型糖尿病中的胰岛素抵抗会损害脂质代谢. 这项研究揭示了胰岛素如何通过Akt2抑制PGC-1alpha,控制肝脂合成,并提供了一个新的治疗点.

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