相关实验视频
Updated: Jul 11, 2026

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
所有八种七碳二 propionate 立体四的不对称合成
Ahmad El-Awa1, Xavier Mollat du Jourdin, Philip L Fuchs
1Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Journal of the American Chemical Society
|June 15, 2007
概括
这项研究详细介绍了一种新方法来合成立体,这是聚 propionate 天然产品的关键组成部分. 该过程涉及二聚体选择性环氧化和立体控制甲基化,产生八种可能的立体四中的七种.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 聚氨酸天然产品是具有显著生物活性的复杂分子.
- 为了获得这些天然产品,对立体交易的有效合成至关重要.
研究的目的:
- 开发一种用于合成立体电路的二分立体选择方法.
- 提供与天然产品合成相关的八种可能的立体交易中的七种.
主要方法:
- 灾难性选择性环氧化埃纳西奥普尔环乙硫.
- 立体控制的环氧乙烯硫的合成和抗甲基化.
- 为了立体化学确认,使用X射线晶体学.
主要成果:
- 对于环氧乙烯硫来说,获得了高产量和二聚体比率.
- 访问所有八种可能的立体交易,其中七种常见于天然产品中.
- 通过X射线结晶学和氧化裂变确认的立体交易,用于进一步的合成.
结论:
- 开发的方法提供了一条通往立体交易的多功能途径.
- 这种方法有助于合成复杂的多酸天然产品.
- 由此产生的非循环型立体基被准备用于加工成更大的分子碎片.
相关概念视频
Carbon Skeletons
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Organic Compounds
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
Constitutional Isomers of Alkanes
Organic compounds of the same molecular formula can have different structural formulas called constitutional isomers, and the phenomenon is known as constitutional isomerism. Alkanes with four or more carbons showing multiple structures with the same molecular formula thereby exhibit constitutional isomerism.
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the branched isomers are given...
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the branched isomers are given...
Conformations of Ethane and Propane
In an organic molecule, free rotation about the carbon-carbon single bond results in energetically different conformers of the molecule. Due to this rotation, called the internal rotation, ethane has two major conformations — staggered and eclipsed.
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
Conformations of Butane
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are degenerate and have...
Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides
Naming Acid Halides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.

