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Updated: May 5, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

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在乳腺癌单一病例中,有限的家族结构和BRCA基因突变状态

Jeffrey N Weitzel1, Veronica I Lagos, Carey A Cullinane

  • 1Department of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA. jweitzel@coh.org

JAMA
|June 21, 2007
PubMed
概括

家庭结构影响遗传性乳腺癌风险. 有限的家族病史增加了BRCA基因突变的患病率,这表明对早期乳腺癌病例需要更新基因测试指南.

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